Cloned (Comment) | Organism |
---|---|
recombinant full-length enzyme and soluble truncated form tagged with FLAG sequence at the N-terminus. expressed in COS7 cells, N-acetylglucosaminyltransferase-IVa | Homo sapiens |
recombinant full-length enzyme and soluble truncated form tagged with FLAG sequence at the N-terminus. expressed in COS7 cells, N-acetylglucosaminyltransferase-IVb | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.118 | - |
UDP-N-acetyl-D-glucosamine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa | Homo sapiens | |
0.242 | - |
UDP-N-acetyl-D-glucosamine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb | Homo sapiens | |
0.341 | - |
UDP-N-acetyl-D-glucosamine | 37°C, pH 7.5, recombinant soluble human flag-GnTIVa | Homo sapiens | |
0.358 | - |
UDP-N-acetyl-D-glucosamine | 37°C, pH 7.5, recombinant soluble human flag-GnTIVa | Homo sapiens | |
0.532 | - |
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa | Homo sapiens | |
0.971 | - |
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa | Homo sapiens | |
1.04 | - |
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant soluble human flag-GnTIVa | Homo sapiens | |
3.19 | - |
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVa | Homo sapiens | |
3.35 | - |
GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb | Homo sapiens | |
5.72 | - |
GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb | Homo sapiens | |
6.94 | - |
GlcNAcbeta1-2Man1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant soluble human flag-GnTIVa | Homo sapiens | |
10.5 | - |
GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | 37°C, pH 7.5, recombinant full-length N-acetylglucosaminyltransferase-IVb | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | Homo sapiens | GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans | UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? | |
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | Homo sapiens | GnT-IVb might contribute to the basal GnT-IV activity in cells | UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | GnT-IVa is primarily responsible for the biosynthesis of complex-type N-glycans | Homo sapiens | UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? | |
UDP-N-acetyl-D-glucosamine + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | GnT-IVb might contribute to the basal GnT-IV activity in cells | Homo sapiens | UDP + 3-(2,4-bis[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | N-acetylglucosaminyltransferase-IVa | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2(GlcNAcbeta1-6)Manalpha1-6(GlcNAcbeta1-2Manalpha1-3)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | N-acetylglucosaminyltransferase-IVb | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | N-acetylglucosaminyltransferase-IVa | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(GlcNAcbeta1-2Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | N-acetylglucosaminyltransferase-IVb | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | N-acetylglucosaminyltransferase-IVa | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GlcNAcbeta1-2Manalpha1-3(Manalpha1-6)Manbeta1-4GlcNAcbeta1-4GlcNAc-2-aminopyridine | N-acetylglucosaminyltransferase-IVb | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT-IVb | - |
Homo sapiens |
GnTIVa | - |
Homo sapiens |
N-acetylglucosaminyltransferase-IVa | - |
Homo sapiens |
N-acetylglucosaminyltransferase-IVb | - |
Homo sapiens |