Inhibitors | Comment | Organism | Structure |
---|---|---|---|
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside | - |
Homo sapiens | |
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-alpha-D-mannopyranoside | - |
Homo sapiens | |
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside | - |
Homo sapiens | |
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside | - |
Homo sapiens | |
additional information | systematic synthesis of four N-glycan units, the branching parts of the bisected and non-bisected N-glycans, from a common core trimannose, giving bisected tetra- and hexasaccharides as well as non-bisected tri- and pentasaccharides, and evaluation as enzyme inhibitors, overview. The competitive GnT-III inhibition assay using the synthetic substrates reveals a vital role for the Manbeta(1-4)GlcNAc moiety, GlcNAc at the alpha1,3-branch is also involved in the interaction. Competitive inhibition, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q09327 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose | Homo sapiens | ? | - |
? | |
UDP-N-acetyl-D-glucosamine + GnGnbi-PA | the bi-branched N-glycan carrying a pyridylamino (PA) group at the reducing terminus (GnGnbi-PA) serves as a typical acceptor substrate and UDP-GlcNAc as a donor substrate | Homo sapiens | UDP + 4-(N-acetyl-beta-D-glucosaminyl)-GnGnbi-PA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GnT-III | - |
Homo sapiens |
N-acetylglucosaminyltransferase III | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.2 | - |
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside | pH and temperature not specified in the publication, versus GnGnbi-PA | Homo sapiens | |
1.4 | - |
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside | pH and temperature not specified in the publication, versus UDP-N-acetyl-D-glucosamine | Homo sapiens | |
1.5 | - |
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside | pH and temperature not specified in the publication, versus UDP-N-acetyl-D-glucosamine | Homo sapiens | |
14 | - |
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside | pH and temperature not specified in the publication, versus GnGnbi-PA | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose. Bisected N-glycans are involved in physiological and pathological processes through the functional regulation of their carrier proteins | Homo sapiens |