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Literature summary for 2.4.1.144 extracted from

  • Rudd, P.M.; Endo, T.; Colominas, C.; Groth, D.; Wheeler, S.F.; Harvey, D.J.; Wormald, M.R.; Serban, H.; Prusiner, S.B.; Kobata, A.; Dwek, R.A.
    Glycosylation differences between the normal and pathogenic prion protein isoforms (1999), Proc. Natl. Acad. Sci. USA, 96, 13044-13049.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mesocricetus auratus in brain cells with down-regulated enzyme activity, normal prion proteins PrPC get conversed to pathogenic prion protein PrPSc due to a lower amount of glycans with bisecting N-acetylglucosamine residues ?
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 ?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
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 forming normal prion protein PrPC and pathogenic prion protein PrPSc
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Source Tissue

Source Tissue Comment Organism Textmining
brain cells forming normal prion protein PrPC with normal enzyme activity, and pathogenic prion protein PrPSc with reduced enzyme activity Mesocricetus auratus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in brain cells with down-regulated enzyme activity, normal prion proteins PrPC get conversed to pathogenic prion protein PrPSc due to a lower amount of glycans with bisecting N-acetylglucosamine residues Mesocricetus auratus ?
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 ?
UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R
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 Mesocricetus auratus UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R incorporates a N-acetylglucosamine residue in beta-1,4-linkage to beta-linked mannosyl, i.e. bisecting N-acetylglucosamine ?

Synonyms

Synonyms Comment Organism
GnTIII
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 Mesocricetus auratus