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Literature summary for 2.4.1.141 extracted from

  • Bickel, T.; Lehle, L.; Schwarz, M.; Aebi, M.; Jakob, C.A.
    Biosynthesis of Lipid-linked Oligosaccharides in Saccharomyces cerevisiae: Alg13p and Alg14p form a complex required for the formation of GlcNAc2-PP-dolichol (2005), J. Biol. Chem., 280, 34500-34506.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol Alg13p protein localizes both to the membrane and cytosol Saccharomyces cerevisiae 5829
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membrane Alg13p protein localizes both to the membrane and cytosol Saccharomyces cerevisiae 16020
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membrane Alg14p protein is exclusively membrane-bound Saccharomyces cerevisiae 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol Saccharomyces cerevisiae second step in the biosynthesis of the unique lipid-linked core oligosaccharide UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P38242
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Saccharomyces cerevisiae P53178
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
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Saccharomyces cerevisiae UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
?
UDP-N-acetyl-alpha-D-glucosamine + N-acetyl-alpha-D-glucosaminyl-diphosphodolichol second step in the biosynthesis of the unique lipid-linked core oligosaccharide Saccharomyces cerevisiae UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphosphodolichol
-
?

Subunits

Subunits Comment Organism
More Alg13p associates with Alg14p to a complex forming the active transferase catalyzing the biosynthesis of GlcNAc2-PP-Dol Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Alg13
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Saccharomyces cerevisiae
Alg14
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Saccharomyces cerevisiae