Cloned (Comment) | Organism |
---|---|
expression in galactosyltransferase-deficient CHO618 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | decorin is less efficiently substituted with glycosaminoglycan chains upon expression of beta4GalT-7(186D) compared to beta4GalT-7-expressing cells. Cells expressing beta4GalT-7206P do not synthesize the proteoglycan form of decorin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + O-beta-D-xylosylprotein | Homo sapiens | in a progeroid patient carrying two point mutations in beta4galactosyltransferase I (ß4GalT-7) only 50% of the decorin core protein molecules are substituted with glycosaminoglycan chains. Tthe ß4GalT-7 mutations directly affect the molecular phenotype of decorin observed in a patient with the progeroid form of Ehlers-Danlos syndrome, which may be a major mechanistic cause for the skin and wound healing defects observed in this patient | UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + O-beta-D-xylosylprotein | in a progeroid patient carrying two point mutations in beta4galactosyltransferase I (ß4GalT-7) only 50% of the decorin core protein molecules are substituted with glycosaminoglycan chains. Tthe ß4GalT-7 mutations directly affect the molecular phenotype of decorin observed in a patient with the progeroid form of Ehlers-Danlos syndrome, which may be a major mechanistic cause for the skin and wound healing defects observed in this patient | Homo sapiens | UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta4galactosyltransferase I | - |
Homo sapiens |
beta4GalT-7 | - |
Homo sapiens |