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Literature summary for 2.4.1.132 extracted from

  • Imamura, K.; Maeda, S.; Kawamura, I.; Matsuyama, K.; Shinohara, N.; Yahiro, Y.; Nagano, S.; Setoguchi, T.; Yokouchi, M.; Ishidou, Y.; Komiya, S.
    Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation (2014), J. Biol. Chem., 289, 9865-9879.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene ALG2, expression analysis by quantitative RT-PCR, coexpression of Alg2 and Runx2 in COS-7 cells, both localizing to different compartments Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information ALG2 downregulation in ST-2 cells by siRNA transfection Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Mus musculus 5783
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9DBE8 gene ALG2
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Mus musculus C57/BL6J Q9DBE8 gene ALG2
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Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
 Mus musculus
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MC3T3-E1 cell a calvarial bone-derived osteoblast cell line Mus musculus
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additional information asparagine-linked glycosylation 2 (Alg2) is commonly downregulated in BMP-2-induced osteoblast differentiation in both MC3T3-E1 and ST-2 cells Mus musculus
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osteoblast
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 Mus musculus
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ST-2 cell
-
 Mus musculus
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Synonyms

Synonyms Comment Organism
asparagine-linked glycosylation 2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus knockdown of human immunodeficiency virus type 1 enhancer-binding protein 3, Hivep3, downregulates Alg2 expression. Expression of the Alg2 gene is reduced upon knockdown of Hivep3 in osteoblastic cells down

General Information

General Information Comment Organism
malfunction loss of Alg2 promotes osteoblast differentiation in ST-2 cells without affecting the protein level of Runx2. Alg2 knockdown does not affect endoplasmic reticulum stress or bone morphogenetic protein, BMP, signaling in ST-2 cells. Atf4,also known as CCAAT/enhancer-binding protein homologous protein (Chop), is mildly upregulated by sAlg2, but only in BMP-2-treated cells. The expression of a target of the Atf6 pathway, heat shock protein 5 (Hspa5), is not altered by loss of Alg2 Mus musculus
metabolism asparagine-linked glycosylation (ALG) is one of the most common protein modification reactions in eukaryotic cells, as many proteins that are translocated across or integrated into the rough endoplasmic reticulum carry N-linked oligosaccharides. Linkage between an asparagine-linked glycosylation mannosyltransferase gene and osteochondrogenesis Mus musculus
physiological function human immunodeficiency virus type 1 enhancer-binding protein 3, Hivep3 or Schnurri-3, Zas3, and Krc, is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. Alg2 suppresses osteoblast differentiation by inhibiting the activity of Runx2. Alg2 silencing suppresses the expression of Creb3l2 and chondrogenesis. Enzyme ALG2 is associated with osteochondrogenesis, Alg2 is a downstream mediator of Hivep3 and suppresses osteogenesis, whereas it promotes chondrogenesis. Regulation analysis, overview Mus musculus