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Literature summary for 2.4.1.129 extracted from

  • Sung, M.T.; Lai, Y.T.; Huang, C.Y.; Chou, L.Y.; Shih, H.W.; Cheng, W.C.; Wong, C.H.; Ma, C.
    Crystal structure of the membrane-bound bifunctional transglycosylase PBP1b from Escherichia coli (2009), Proc. Natl. Acad. Sci. USA, 106, 8824-8829.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
in complex with moenomycin, sitting drop vapor diffusion method, using 1.2 M sodium formate Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Moenomycin
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0183
-
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol purified wild type enzyme Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Organism

Organism UniProt Comment Textmining
Escherichia coli P02919
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel chelation column chromatography and Superdex 200 gel filtration Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol
-
Escherichia coli [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n+1-diphosphoundecaprenol + undecaprenyl diphosphate
-
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Synonyms

Synonyms Comment Organism
murein synthase
-
Escherichia coli
PBP1b
-
Escherichia coli
penicillin-binding protein 1B bifunctional transglycosylase Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.14
-
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol purified wild type enzyme Escherichia coli

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
174
-
[GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol purified wild type enzyme Escherichia coli