Protein Variants | Comment | Organism |
---|---|---|
D77A | the PMT1 mutant shows 71.95% activity compared to the wild type enzyme | Homo sapiens |
D77A/E78A | the PMT1 mutant shows 0.19% activity compared to the wild type enzyme | Homo sapiens |
D77A/E78A | the PMT1 mutant shows 3.59% activity compared to the wild type enzyme | Homo sapiens |
D77A/E78A/D92A/E93A | the PMT1/PMT2 mutant shows 0.24% activity compared to the wild type enzyme | Homo sapiens |
D80A | the PMT4 mutant shows 3.21% activity compared to the wild type enzyme | Homo sapiens |
D80E | the PMT4 mutant shows 52.98% activity compared to the wild type enzyme | Homo sapiens |
D80E/E81D | the PMT4 mutant shows 116.54% activity compared to the wild type enzyme | Homo sapiens |
D92A/E93A | the PMT2 mutant shows 3.63% activity compared to the wild type enzyme | Homo sapiens |
D96A | the PMT1 mutant shows 63.21% activity compared to the wild type enzyme | Homo sapiens |
E78A | the PMT1 mutant shows 46.68% activity compared to the wild type enzyme | Homo sapiens |
E81A | the PMT4 mutant shows 1.43% activity compared to the wild type enzyme | Homo sapiens |
E81D | the PMT4 mutant shows 46.59% activity compared to the wild type enzyme | Homo sapiens |
F76A | the PMT1 mutant shows 78.79% activity compared to the wild type enzyme | Homo sapiens |
F81A | the PMT1 mutant shows 71.71% activity compared to the wild type enzyme | Homo sapiens |
H80A | the PMT1 mutant shows 83.03% activity compared to the wild type enzyme | Homo sapiens |
H98A | the PMT1 mutant shows 62.77% activity compared to the wild type enzyme | Homo sapiens |
P100A | the PMT1 mutant shows 59.67% activity compared to the wild type enzyme | Homo sapiens |
P99A | the PMT1 mutant shows 61.77% activity compared to the wild type enzyme | Homo sapiens |
V97A | the PMT1 mutant shows 80.23% activity compared to the wild type enzyme | Homo sapiens |
Y88A | the PMT1 mutant shows 73.79% activity compared to the wild type enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
membrane | a membrane protein | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
x * 88000, Pmt2p | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dolichyl phosphate D-mannose + N-acetyl-SSSSS | worst substrate | Homo sapiens | dolichyl phosphate + O-D-mannosyl-N-acetyl-SSSSS | - |
? | |
dolichyl phosphate D-mannose + N-acetyl-YASAV | - |
Homo sapiens | dolichyl phosphate + O-D-mannosyl-N-acetyl-YASAV | - |
? | |
dolichyl phosphate D-mannose + N-acetyl-YATAV | best substrate | Homo sapiens | dolichyl phosphate + O-D-mannosyl-N-acetyl-YATAV | - |
? | |
dolichyl phosphate D-mannose + N-acetyl-YATAVK-biotin | N-acetyl-YATAVK-biotin preferentially reacts with isoform Pmt1p | Homo sapiens | dolichyl phosphate + O-D-mannosyl-N-acetyl-YATAVK-biotin | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 88000, Pmt2p | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
dolichyl-phosphate-mannose-protein mannosyltransferase 1 | - |
Homo sapiens |
PMT | - |
Homo sapiens |
Pmt1p-Pmt2p | - |
Homo sapiens |
Pmt4p | - |
Homo sapiens |