Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.109 extracted from

  • Akasaka-Manya, K.; Manya, H.; Hayashi, M.; Endo, T.
    Different roles of the two components of human protein O-mannosyltransferase, POMT1 and POMT2 (2011), Biochem. Biophys. Res. Commun., 411, 721-725.
    View publication on PubMed
Search for more literature for 2.4.1.109

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E44A inactive Homo sapiens
E86A the mutant shows about 70% activity compared to the wild type enzyme Homo sapiens
R105A inactive Homo sapiens
R145A the mutant shows about 130% activity compared to the wild type enzyme Homo sapiens
R30A the mutant shows less than 10% activity compared to the wild type enzyme Homo sapiens
R72A the mutant shows about 65% activity compared to the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dolichyl phosphate D-mannose + glutathione-S-transferase fusion alpha-dystroglycan
-
 Homo sapiens dolichyl phosphate + O-D-mannosyl-[glutathione-S-transferase fusion alpha-dystroglycan]
-
 ?

Synonyms

Synonyms Comment Organism
dolichyl-phosphate-mannose-protein mannosyltransferase 1
-
 Homo sapiens
POMT1
-
 Homo sapiens
POMT2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism protein O-mannosyltransferase 1 (POMT1) and its homolog, POMT2, are responsible for the catalysis of the first step in O-mannosyl glycan synthesis Homo sapiens