Application | Comment | Organism |
---|---|---|
diagnostics | C2GnT1 might become a prognostic factor for endometrial carcinoma. Patients with C2GnT1 overexpression show significantly shorter survival, multivariable analysis also indicate that 2GnT1 overexpression is an independent prognostic factor | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene GCNT2, recombinant expression in COS7 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene GCNT2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endometrial carcinoma cell | expression of C2GnT1 in 84 cases of endometrioid-type endometrial carcinoma, 15 cases of endometrial hyperplasia, and 30 normal endometria, immunohistochemic analysis, overview. C2GnT1 is strongly expressed at the invasive tumour front in several cases | Homo sapiens | - |
additional information | topologically, C2GnT1 is strongly expressed at sites of deep myometrial invasion | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
C2GnT1 | - |
Homo sapiens |
core 2 beta1,6-N-acetylglucosaminyl transferase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | C2GnT1 synthesizes the core 2 branching structure by catalysing the transfer of GlcNAc from UDP-GlcNAc with a beta1,6-linkage to GalNAc of the core 1 chain. On this core 2 branch, several tumour-associated carbohydrate structures, such as sLex and sLea, are synthesized. The enzyme may be associated with the biological aggressiveness of tumour cells, relationship between the expression of C2GnT1 and clinicopathological parameters of patients with endometrial carcinoma, overview | Homo sapiens |