Application | Comment | Organism |
---|---|---|
diagnostics | possible role of GCNT3 gene expression as prognostic marker in colon cancer. Low CNT3 expression is a promising prognostic biomarker for colon cancer that could be used to identify early-stage colon cancer patients at high risk of relapse. The enzyme might also constitute a biomarker to monitor tumour response to chemotherapy in cancer patients | Homo sapiens |
medicine | clinical relevance of the differential expression of the glycosyltransferase gene GCNT3 in colon cancer, clinicopathological parameters, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene GCNT3, quantitative reverse-transcription PCR enzyme expression analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
Golgi apparatus | - |
Homo sapiens | 5794 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95395 | gene GCNT3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon cancer cell | differential expression of GCNT3 gene among tumour samples from stage II colon cancer patients by quantitative reverse-transcription PCR, overview | Homo sapiens | - |
additional information | the isozyme is distributed in mucin-secreting tissues along the gastrointestinal tract | Homo sapiens | - |
pancreatic cancer cell | - |
Homo sapiens | - |
SW-620 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
c2GnT-M | - |
Homo sapiens |
gcnt3 | - |
Homo sapiens |
mucin-type core 2 1,6-N-acetylglucosaminyltransferase enzyme | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the three chemotherapeutic agents, with different mechanism of action, 5-fluorouracil, bortezomib and paclitaxel significantly induce GCNT3 expression in several cancer cells, but not in drug-unreponsive cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the isozyme shows tumour suppressor properties, together with a role of mucin production in chemotherapy sensitivity in pancreatic cancer | Homo sapiens |