Literature summary for 2.4.1.102 extracted from

Lim, Y.C.; Xie, H.; Come, C.E.; Alexander, S.I.; Grusby, M.J.; Lichtman, A.H.; Luscinskas, F.W.
IL-12, STAT4-dependent up-regulation of CD4+ T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands (2001), J. Immunol., 167, 4476-4484.

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Activating Compound

Activating Compound	Comment	Organism	Structure
cytokines	induction by IL-4 and IL-12/STAT4	Mus musculus
additional information	no induction by Ag+	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R	Mus musculus	involved in regulation of downstream intracellular signal transduction pathways	UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R	-	?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R	Mus musculus	increased activity during E- and P-selectin ligand biosynthesis	UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	inducible by cytokines IL-4, and IL-12/STAT4	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
T-lymphocyte	wild-type and transgenic CD4+ T cell lines, induction by cytokines IL-4, and IL-12/STAT4	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R	-	Mus musculus	UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R	-	?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R	involved in regulation of downstream intracellular signal transduction pathways	Mus musculus	UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R	-	?
UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R	increased activity during E- and P-selectin ligand biosynthesis	Mus musculus	UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R	-	?
UDP-N-acetyl-D-glucosamine + p-nitrophenyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside	-	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
core 2 beta-1,6-N-acetylglucosaminyltransferase	-	Mus musculus

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Release 2023.1 (January 2023)