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Literature summary for 2.4.1.1 extracted from

  • Kantsadi, A.L.; Manta, S.; Psarra, A.M.; Dimopoulou, A.; Kiritsis, C.; Parmenopoulou, V.; Skamnaki, V.T.; Zoumpoulakis, P.; Zographos, S.E.; Leonidas, D.D.; Komiotis, D.
    The binding of C5-alkynyl and alkylfurano[2,3-d]pyrimidine glucopyranonucleosides to glycogen phosphorylase b: synthesis, biochemical and biological assessment (2012), Eur. J. Med. Chem., 54, 740-749.
    View publication on PubMed
Search for more literature for 2.4.1.1

Activating Compound

Activating Compound Comment Organism Structure
AMP
-
 Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil
-
 Oryctolagus cuniculus
1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil
-
 Oryctolagus cuniculus
1-(beta-D-glucopyranosyl)-5-ethynyluracil cytotoxic effect on Hep-G2 cells Oryctolagus cuniculus
1-(beta-D-glucopyranosyl)-5-iodouracil
-
 Oryctolagus cuniculus
3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
 Oryctolagus cuniculus
3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one
-
 Oryctolagus cuniculus
alpha-D-glucose physiological inhibitor Oryctolagus cuniculus
additional information synthesis of glucopyranonucleosides in the 5-alkynyl- and 6-alkylfurano[2,3-d]pyrimidine series, overview Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate Oryctolagus cuniculus
-
 [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[(1->4)-alpha-D-glucosyl]n + phosphate
-
 Oryctolagus cuniculus [(1->4)-alpha-D-glucosyl]n-1 + alpha-D-glucose 1-phosphate
-
 r

Synonyms

Synonyms Comment Organism
glycogen phosphorylase b
-
 Oryctolagus cuniculus
GPb
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Oryctolagus cuniculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.001
-
 1-(beta-D-glucopyranosyl)-5-iodouracil pH 6.8, 30°C Oryctolagus cuniculus
0.0047
-
 1-(beta-D-glucopyranosyl)-5-ethynyluracil pH 6.8, 30°C Oryctolagus cuniculus
0.0324
-
 3-(beta-D-glucopyranosyl)-6-propyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one pH 6.8, 30°C Oryctolagus cuniculus
0.0334
-
 3-(beta-D-glucopyranosyl)-6-pentyl-2,3-dihydro-furano-[2,3-d]pyrimidin-2-one pH 6.8, 30°C Oryctolagus cuniculus
0.303
-
 1-(beta-D-glucopyranosyl)-5-(pent-1-yn-1-yl)uracil pH 6.8, 30°C Oryctolagus cuniculus
1.7
-
 alpha-D-glucose pH 6.8, 30°C Oryctolagus cuniculus
3.204
-
 1-(beta-D-glucopyranosyl)-5-(hept-1-yn-1-yl)uracil pH 6.8, 30°C Oryctolagus cuniculus

General Information

General Information Comment Organism
additional information structural analysis of molecular elements that govern molecular recognition by the catalytic site of the enzyme with emphasis in the beta-pocket environment, overview Oryctolagus cuniculus