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Literature summary for 2.4.1.1 extracted from

  • Alexacou, K.M.; Tenchiu Deleanu, A.C.; Chrysina, E.D.; Charavgi, M.D.; Kostas, I.D.; Zographos, S.E.; Oikonomakos, N.G.; Leonidas, D.D.
    The binding of beta-D-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: a new class of inhibitors (2010), Bioorg. Med. Chem., 18, 7911-7922.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
purified enzyme bound to diverse inhibitor molecules, X-ray diffraction structure determination and analysis, modeling Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibitory efficiency and inhibition kinetics of beta-D-glucopyranosyl-thiosemicarbazone derivatives as glycogen phosphorylase inhibitors, binding analysis, overview Oryctolagus cuniculus
N-([(2E)-2-[4-(trifluoromethyl)benzylidene]hydrazinyl]carbonothioyl)-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(2-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(2-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(3-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(3-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(3-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-fluorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-methoxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-methylbenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(4-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus
N-[[(2E)-2-(pyridin-4-ylmethylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
-
Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from skeletal muscle Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
Oryctolagus cuniculus
-

Synonyms

Synonyms Comment Organism
glycogen phosphorylase
-
Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
assay at Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.7
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-fluorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
23.2
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(3-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
25.7
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
26.6
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
28.3
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
50.4
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(3-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
93.2
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-bromobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
180
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(3-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
192.4
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-methylbenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
200
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(pyridin-4-ylmethylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
340.5
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-hydroxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
370
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(2-chlorobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
406.5
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(4-methoxybenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
484.2
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-[[(2E)-2-(2-nitrobenzylidene)hydrazinyl]carbonothioyl]-beta-D-glucopyranosylamine
524.3
-
pH 6.8, temperature not specified in the publication Oryctolagus cuniculus N-([(2E)-2-[4-(trifluoromethyl)benzylidene]hydrazinyl]carbonothioyl)-beta-D-glucopyranosylamine