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Literature summary for 2.4.1.1 extracted from

  • Hampson, L.J.; Mackin, P.; Agius, L.
    Stimulation of glycogen synthesis and inactivation of phosphorylase in hepatocytes by serotonergic mechanisms, and counter-regulation by atypical antipsychotic drugs (2007), Diabetologia, 50, 1743-1751.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte stimulation and inhibition of glycogen synthesis in hepatocytes by serotonergic mechanisms. The former effects are associated with the inactivation of phosphorylase and are counteracted by atypical antipsychotic drugs that cause hepatic insulin resistance. Antagonism of hepatic serotonergic mechanisms may be a component of the hepatic dysregulation caused by antipsychotic drugs that predispose to type 2 diabetes Rattus norvegicus
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Synonyms

Synonyms Comment Organism
phosphorylase a
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Rattus norvegicus