Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | - |
Mus musculus | |
AMP | - |
Homo sapiens | |
AMP | - |
Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-[(2S)-2-([(5-chloro-1H-indol-2-yl)carbonyl]amino)-3-phenylpropanoyl]azetidine-3-carboxylic acid | i.e. CP-403700, 50% inhibition at 0.1 microM in presence of 1 mM phosphate. In presence of 1 mM phosphate plus 8 mM glucose, 50% inhibition at 0.05 microM. Presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect | Homo sapiens | |
1-[(2S)-2-([(5-chloro-1H-indol-2-yl)carbonyl]amino)-3-phenylpropanoyl]azetidine-3-carboxylic acid | i.e. CP-403700, indole-site inhibitor, suppression of hepatic glycogenolysis | Rattus norvegicus | |
ADP | - |
Homo sapiens | |
ATP | - |
Homo sapiens | |
CP-316819 | indole-site inhibitor, presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect | Homo sapiens | |
CP-316819 | indole-site inhibitor, oral administration to diabetic ob/ob mice results in lowering of plasma glucose concentration by 40% at 50 mg per kg. Measured drug concentration in the liver is about 100fold higher than the in vitro IC50 values | Mus musculus | |
CP-316819 | indole-site inhibitor, suppression of hepatic glycogenolysis | Rattus norvegicus | |
CP-320626 | indole-site inhibitor, presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect | Homo sapiens | |
CP-320626 | indole-site inhibitor, suppression of hepatic glycogenolysis | Rattus norvegicus | |
CP-380867 | indole-site inhibitor, presence of endogenous inhibitors such as D-glucose, ADP, ATP, D-fructose 1-phosphate, D-glucose 6-phosphate, UDP-glucose markedly reduces the inhibitory effect | Homo sapiens | |
CP-380867 | indole-site inhibitor, suppression of hepatic glycogenolysis | Rattus norvegicus | |
D-Fructose 1-phosphate | - |
Homo sapiens | |
D-glucose | - |
Homo sapiens | |
D-glucose 6-phosphate | - |
Homo sapiens | |
UDP-glucose | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
recombinant phosphorylase a | - |
Mus musculus | - |
diabetic ob/ob mice | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |