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Literature summary for 2.4.1.1 extracted from
- Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures (2004), Nucleosides Nucleotides Nucleic Acids, 23, 1235-1239.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Arg-vasopressin and phenylephrine activate the enzyme through the phosphoinositide cascade | Rattus norvegicus | |
| protein kinase A | activates the enzyme via phosphorylation, which is induced by dibutyryl cAMP, forskolin, and glucagon | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Caffeine | - |
Rattus norvegicus |  |
| CP-91149 | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (1,4-alpha-D-glucosyl)n + phosphate | Rattus norvegicus | polysaccharide substrate is glycogen | (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate | - |
? | |
| additional information | Rattus norvegicus | increased enzyme activity increases 5-phosphoribosyl-1-diphosphate availability in hepatocyte cultures and vice versa, glycogenolysis is a major contributor to PRPP generation in liver tissue in the basal state | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Wistar rats | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | phosphorylation and dephosphorylation of the enzyme regulates its activity and is catalyzed by a phosphorylase phosphatase and protein kinase A | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (1,4-alpha-D-glucosyl)n + phosphate | polysaccharide substrate is glycogen | Rattus norvegicus | (1,4-alpha-D-glucosyl)n-1 + alpha-D-glucose 1-phosphate | - |
? | |
| additional information | increased enzyme activity increases 5-phosphoribosyl-1-diphosphate availability in hepatocyte cultures and vice versa, glycogenolysis is a major contributor to PRPP generation in liver tissue in the basal state | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glycogen phosphorylase | - |
Rattus norvegicus |
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