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Literature summary for 2.3.3.8 extracted from

  • Chen, H.; He, X.; Geng, H.; Liu, H.
    Physiological characterization of ATP-citrate lyase in Aspergillus niger (2014), J. Ind. Microbiol. Biotechnol., 41, 721-731.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Aspergillus niger

Protein Variants

Protein Variants Comment Organism
H305A inactive mutant of isoform Acl1 Aspergillus niger

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Aspergillus niger 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate Aspergillus niger
-
ATP + citrate + CoA
-
?
ADP + phosphate + acetyl-CoA + oxaloacetate Aspergillus niger ATCC 1015
-
ATP + citrate + CoA
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus niger
-
-
-
Aspergillus niger ATCC 1015
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Aspergillus niger

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate
-
Aspergillus niger ATP + citrate + CoA
-
?
ADP + phosphate + acetyl-CoA + oxaloacetate
-
Aspergillus niger ATCC 1015 ATP + citrate + CoA
-
?
additional information only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein Aspergillus niger ?
-
?
additional information only the complex of Acl1 and Acl2 shows AT P-citrate lyase activity, no enzyme activities are detected with the individual protein Aspergillus niger ATCC 1015 ?
-
?

Synonyms

Synonyms Comment Organism
ACL1 isoform Aspergillus niger
ACL2 isoform Aspergillus niger
ACLY
-
Aspergillus niger
ATP-citrate lyase
-
Aspergillus niger

General Information

General Information Comment Organism
physiological function isoforms Acl1 and Acl2 coordinately modulate the cytoplasmic acetyl-CoA levels to regulate growth, development, and citric acid synthesis in Aspergillus niger Aspergillus niger