Crystallization (Comment) | Organism |
---|---|
in the presence of tartrate, ATP and magnesium ions | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-2,2-difluorocitrate | - |
Homo sapiens | |
(+)-2,2-difluorocitrate | - |
Mus musculus | |
(-)-2,2-difluorocitrate | - |
Homo sapiens | |
(-)-2,2-difluorocitrate | - |
Mus musculus | |
(-)-Hydroxycitrate | potent inhibitor | Homo sapiens | |
(-)-Hydroxycitrate | potent inhibitor | Mus musculus | |
radicicol | noncompetitive inhibitor | Homo sapiens | |
radicicol | noncompetitive inhibitor | Mus musculus | |
SB-204990 | - |
Homo sapiens | |
SB-204990 | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | Mus musculus | - |
acetyl-CoA + oxaloacetate + ADP + phosphate | - |
ir | |
ATP + citrate + CoA | Homo sapiens | - |
acetyl-CoA + oxaloacetate + ADP + phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of the enzyme at Thr446, Ser450 and Ser454 is enhanced by glucagon, insulin, vasopressin and transforming growth factor beta1 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | low expression | Mus musculus | - |
brain | low expression | Homo sapiens | - |
colonic adenocarcinoma cell | - |
Homo sapiens | - |
glioblastoma cell | - |
Homo sapiens | - |
heart | low expression | Mus musculus | - |
heart | low expression | Homo sapiens | - |
liver | high expression | Mus musculus | - |
liver | high expression | Homo sapiens | - |
MEF cell | - |
Mus musculus | - |
muscle | low expression | Mus musculus | - |
muscle | low expression | Homo sapiens | - |
pro-B-lymphocyte | - |
Mus musculus | - |
small intestine | low expression | Mus musculus | - |
small intestine | low expression | Homo sapiens | - |
white adipose tissue | high expression | Mus musculus | - |
white adipose tissue | high expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | - |
Mus musculus | acetyl-CoA + oxaloacetate + ADP + phosphate | - |
ir | |
ATP + citrate + CoA | - |
Homo sapiens | acetyl-CoA + oxaloacetate + ADP + phosphate | - |
ir |
Subunits | Comment | Organism |
---|---|---|
homotetramer | - |
Mus musculus |
homotetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ACLY | - |
Mus musculus |
ACLY | - |
Homo sapiens |
ATP-citrate lyase | - |
Mus musculus |
ATP-citrate lyase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | sterol regulatory element binding protein-1 up-regulates the enzyme at mRNA level via Akt signaling | up |
Homo sapiens | sterol regulatory element binding protein-1 up-regulates the enzyme at mRNA level via Akt signaling | up |
General Information | Comment | Organism |
---|---|---|
malfunction | overexpression of the enzyme is observed in nonalcoholic fatty liver disease. Increased enzyme activity is associated with hypocituria, nonalcoholic fatty liver disease, and tumor cell growth. Decreased enzyme activity is associated with type 2 diabetes. ACLY knockdown or inhibition leads to a decrease in glucose-induced insulin secretion | Homo sapiens |
metabolism | the enzyme is involved in citrate metabolism | Mus musculus |
metabolism | the enzyme is involved in citrate metabolism | Homo sapiens |
physiological function | the enzyme is essentially required for embryonic development. Increased enzyme activity is found in the fetal development of the brain | Mus musculus |