Literature summary for 2.3.3.8 extracted from

Ma, Z.; Chu, C.; Cheng, D.
A novel direct homogeneous assay for ATP citrate lyase (2009), J. Lipid Res., 50, 2131-2135.

Search for more literature for 2.3.3.8

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Baculovirus Bac-N-Blue expression system	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
BMS-303141	-	Homo sapiens
Hydroxycitrate	competitive	Homo sapiens
SB-201076	-	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.004	-	CoA	direct assay	Homo sapiens
0.014	-	CoA	coupled assay	Homo sapiens
0.047	-	ATP	direct assay	Homo sapiens
0.0738	-	citrate	direct assay	Homo sapiens
0.098	-	citrate	coupled assay	Homo sapiens
0.12	-	ATP	coupled assay	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
ammonium sulfate precipitation, ion exchange chromatography (DEAE), gel filtration	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
citrate + CoA + ATP	-	Homo sapiens	acetyl-CoA + oxaloacetate + ADP + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
ATP citrate lyase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00015	-	Hydroxycitrate	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00094	-	-	Homo sapiens	BMS-303141

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Release 2023.1 (January 2023)