Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Hydroxycitrate | - |
Homo sapiens | |
radiciol | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
120608 | - |
x * 120608, calculated, identified by mass spectrometry | Homo sapiens |
125000 | - |
x * 125000, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P53396 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioblastoma cell | - |
Homo sapiens | - |
LN-229 cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + citrate + CoA | - |
Homo sapiens | ADP + phosphate + acetyl-CoA + oxaloacetate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 125000, SDS-PAGE | Homo sapiens |
? | x * 120608, calculated, identified by mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
ACLY | - |
Homo sapiens |
ATP citrate lyase isoform 2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | there are about 3fold increased levels of the enzyme in glioblastoma pseudopodia compared to unmigrated cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of the enzyme suppresses in vitro glioblastoma cell migration, clonogenicity and brain invasion under glycolytic conditions and enhances the suppressive effects of a Met inhibitor on cell migration | Homo sapiens |
physiological function | ATP citrate lyase is a positive regulator of glycolytic function in glioblastomas | Homo sapiens |