Application | Comment | Organism |
---|---|---|
medicine | stable knockdown of ATP citrate synthase significantly impairs Akt-mediated tumorigenesis in vivo | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockout mutant leads to a significant impairment of glucose-dependent lipid synthesis and an elevation of mitochondrial membrane potential. Cells lacking ATP citrate synthase display decreased cytokine-stimulated cell proliferation. In contrast, these cells resist cell death induced by either cytokine or glucose withdrawal. The mutation significantly impairs Akt-mediated tumorigenesis in vivo | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
FL5.12 cell | - |
Mus musculus | - |