Literature summary for 2.3.3.8 extracted from

Bauer, D.E.; Hatzivassiliou, G.; Zhao, F.; Andreadis, C.; Thompson, C.B.
ATP citrate lyase is an important component of cell growth and transformation (2005), Oncogene, 24, 6314-6322.

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Application

Application	Comment	Organism
medicine	stable knockdown of ATP citrate synthase significantly impairs Akt-mediated tumorigenesis in vivo	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	enzyme knockout mutant leads to a significant impairment of glucose-dependent lipid synthesis and an elevation of mitochondrial membrane potential. Cells lacking ATP citrate synthase display decreased cytokine-stimulated cell proliferation. In contrast, these cells resist cell death induced by either cytokine or glucose withdrawal. The mutation significantly impairs Akt-mediated tumorigenesis in vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
FL5.12 cell	-	Mus musculus	-

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Release 2023.1 (January 2023)