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Literature summary for 2.3.3.8 extracted from

  • Spector, L.B.
    Citrate cleavage and related enzymes (1972), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 7, 357-389.
No PubMed abstract available
Search for more literature for 2.3.3.8

Activating Compound

Activating Compound Comment Organism Structure
additional information 6-8 very reactive sulfhydryl groups appear to be essential for activity Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0098
-
 acetyl-CoA
-
 Rattus norvegicus
0.177
-
 oxaloacetate
-
 Rattus norvegicus
0.178
-
 ATP
-
 Rattus norvegicus
0.588
-
 citrate
-
 Rattus norvegicus
1.49
-
 phosphate
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Columba livia
-
-
-
Gallus gallus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Oxidation Stability

Oxidation Stability Organism
rapid loss of activity in air at 3°C in Tris buffer Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA mechanism Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Gallus gallus
-
brain
-
 Rattus norvegicus
-
brain
-
 Bos taurus
-
heart
-
 Sus scrofa
-
liver
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-
liver
-
 Columba livia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphate + acetyl-CoA + oxaloacetate
-
 Rattus norvegicus ATP + citrate + CoA
-
 r
ATP + citrate + CoA
-
 Sus scrofa ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA
-
 Bos taurus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA
-
 Oryctolagus cuniculus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA
-
 Columba livia ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA specific for citrate Gallus gallus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA specific for citrate Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 ?
ATP + citrate + CoA specific for citrate Rattus norvegicus ADP + phosphate + acetyl-CoA + oxaloacetate
-
 r