Literature summary for 2.3.3.10 extracted from

Pojer, F.; Ferrer, J.L.; Richard, S.B.; Nagegowda, D.A.; Chye, M.L.; Bach, T.J.; Noel, J.P.
Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases (2006), Proc. Natl. Acad. Sci. USA, 103, 11491-11496.

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Application

Application	Comment	Organism
synthesis	use of crystal structure of enzyme in complex with inhibitor (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid as starting point for structure-based design of inhibitors	Brassica juncea

Crystallization (Commentary)

Crystallization (Comment)	Organism
bound covalently via Cys 117 to inhibitor (E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid, and in complex with acetyl-CoA and hydroxymethylglutaryl-CoA	Brassica juncea

Inhibitors

Inhibitors	Comment	Organism	Structure
(E,E)-11-(3-hydroxymethyl-4-oxo-2-oxytanyl)-3,5,7-trimethyl-2,4-undecadienoic acid	i.e. F-244	Brassica juncea

Organism

Organism	UniProt	Comment	Textmining
Brassica juncea	-	-	-

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Release 2023.1 (January 2023)