Cloned (Comment) | Organism |
---|---|
pig mitochondrial HMG-CoA synthase encodes an active enzyme in the eukaryotic cell line Mev-1 and in Escherichia coli BL21 (DE3) | Sus scrofa |
rat mitochondrial HMG-CoA synthase encodes an active enzyme in the eukaryotic cell line Mev-1 in Escherichia coli BL21 (DE3) | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.695 | - |
acetyl-CoA | - |
Sus scrofa | |
0.811 | - |
acetyl-CoA | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
mitochondrion | - |
Sus scrofa | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
recombinant enzyme, epressed in Mev-1 cells | Sus scrofa |
56000 | - |
recombinant enzyme, epressed in Escherichia coli | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Sus scrofa | pathway converting acetyl-CoA to ketone bodies | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus Sprague-Dawley | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Sprague-Dawley | - |
Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Sus scrofa | - |
piglet | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
liver | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | pathway converting acetyl-CoA to ketone bodies | Sus scrofa | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
ir | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus Sprague-Dawley | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |