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Literature summary for 2.3.3.10 extracted from

  • Miziorko, H.M.; Clinkenbeard, K.D.; Reed, W.D.; Lane, M.D.
    3-Hydroxy-3-methylglutaryl coenzyme A synthase (1975), J. Biol. Chem., 250, 5768-5773.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
chloride
-
Saccharomyces cerevisiae
potassium phosphate
-
Saccharomyces cerevisiae
Sodium phosphate
-
Saccharomyces cerevisiae
sulfate
-
Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
acetoacetyl-CoA
-
Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
2 * 53000, SDS-PAGE Gallus gallus
105000
-
sedimentation equlibrium Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O Saccharomyces cerevisiae
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially Saccharomyces cerevisiae

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 3'-dephospho-CoA + H2O
-
Gallus gallus acetyldephospho-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O
-
Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + acetoacetyl-CoA + H2O
-
Saccharomyces cerevisiae (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?
acetyl-CoA + cysteamine + H2O
-
Gallus gallus ? + CoA
-
?
acetyl-CoA + H2O
-
Gallus gallus acetate + CoA
-
?

Subunits

Subunits Comment Organism
dimer 2 * 53000, SDS-PAGE Gallus gallus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.008
-
acetoacetyl-CoA
-
Saccharomyces cerevisiae