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Literature summary for 2.3.3.10 extracted from
- Properties and subcellular distribution of enzymes required for acetoacetate biosynthesis in chicken liver (1973), Biochim. Biophys. Acta, 297, 22-30.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Gallus gallus |  |
| Zn2+ | - |
Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Gallus gallus | 5737 | - |
| cytoplasm | - |
Cavia porcellus | 5737 | - |
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
| mitochondrion | - |
Gallus gallus | 5739 | - |
| mitochondrion | - |
Cavia porcellus | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | increases acetoacetate synthesis activity | Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + acetoacetyl-CoA + H2O | Cavia porcellus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | acetoacetate biosynthesis, 3-hydroxy-3-methylglutaryl-CoA pathway | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
guinea pig | - |
| Gallus gallus | - |
chicken | - |
| Rattus norvegicus | - |
rat | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00083 | - |
mitochondrial pellet | Gallus gallus |
| 0.00133 | - |
mitochondrial pellet, 0.25 M sucrose | Gallus gallus |
| 0.00245 | - |
disrupted mitochondria, 0.25 M sucrose | Gallus gallus |
| 0.00288 | - |
mitochondrial pellet, 0.50 M sucrose | Gallus gallus |
| 0.00325 | - |
mitochondrial pellet, 0.88 M sucrose | Gallus gallus |
| 0.00485 | - |
homogenate | Gallus gallus |
| 0.00567 | - |
disrupted mitochondria, 0.50 M sucrose | Gallus gallus |
| 0.00792 | - |
disrupted mitochondria, 0.88 M sucrose | Gallus gallus |
| 0.00922 | - |
mitochondrial supernatant | Gallus gallus |
| 0.00958 | - |
mitochondrial supernatant, 0.88 M sucrose | Gallus gallus |
| 0.01053 | - |
mitochondrial supernatant, 0.50 M sucrose | Gallus gallus |
| 0.0111 | - |
mitochondrial supernatant, 0.25 M sucrose | Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | - |
Cavia porcellus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | acetoacetate biosynthesis, 3-hydroxy-3-methylglutaryl-CoA pathway | Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
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