Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | a nonessential RIND/PHD finger protein that constitutively shuttles between cytoplasm and nucelus | Saccharomyces cerevisiae | 5737 | - |
nucleus | a nonessential RIND/PHD finger protein that constitutively shuttles between cytoplasm and nucelus | Saccharomyces cerevisiae | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | Asr1p is involved in calcium signalling. The interaction with calmodulin occurs in vivo and depends on physiological concentrations of Ca2+. A plataeu is reached at 100-500 nM CaCl2 | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
S-ubiquitinyl-[RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-L-lysine22 = [RING-E3-ubiquitin-carrier protein]-L-cysteine + N6-ubiquitinyl-[calmodulin]-L-lysine22 | calmodilin is a small calcium binding protein that is able to transduce an influx of calcium ions to effector proteins. Purified Asr1p E3 ligase, the E1 enzyme and the E2 enzyme UbcH5a are sufficient for in vitro ubiquitylation of calmodulin, requiring a function Asr1p Ring domain. Asr1p specifically ubiquitylates calmodulin | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in vivo calmodulin is ubiquitylated at lysine 22 | Saccharomyces cerevisiae | ? | - |
? | |
additional information | purified Asr1p E3 ligase, the E1 enzyme and the E2 enzyme UbcH5a are sufficient for in vitro ubiquitylation of calmodulin, requiring a function Asr1p Ring domain | Saccharomyces cerevisiae | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | two putitive calmodulin motifs wihin Asr1p are identified that are sufficient and necessary for interaction with calmodulin | Saccharomyces cerevisiae |
Synonyms | Comment | Organism |
---|---|---|
Asr1p | - |
Saccharomyces cerevisiae |
More | formerly EC 6.3.2.21 | Saccharomyces cerevisiae |
ubiquitin E3 ligase | - |
Saccharomyces cerevisiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Saccharomyces cerevisiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | involved in calcium signalling. The interaction with calmodulin occurs in vivo and depends on physiological concentrations of Ca2+ | Saccharomyces cerevisiae |