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Literature summary for 2.3.2.B11 extracted from

  • Fries, T.; Frank, R.; Bailer, S.M.
    The Saccharomyces cerevisiae ubiquitin E3 ligase Asr1p targets calmodulin for ubiquitylation (2011), Biochem. Biophys. Res. Commun., 411, 197-201.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm a nonessential RIND/PHD finger protein that constitutively shuttles between cytoplasm and nucelus Saccharomyces cerevisiae 5737
-
nucleus a nonessential RIND/PHD finger protein that constitutively shuttles between cytoplasm and nucelus Saccharomyces cerevisiae 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Asr1p is involved in calcium signalling. The interaction with calmodulin occurs in vivo and depends on physiological concentrations of Ca2+. A plataeu is reached at 100-500 nM CaCl2 Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Reaction

Reaction Comment Organism Reaction ID
S-ubiquitinyl-[RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-L-lysine22 = [RING-E3-ubiquitin-carrier protein]-L-cysteine + N6-ubiquitinyl-[calmodulin]-L-lysine22 calmodilin is a small calcium binding protein that is able to transduce an influx of calcium ions to effector proteins. Purified Asr1p E3 ligase, the E1 enzyme and the E2 enzyme UbcH5a are sufficient for in vitro ubiquitylation of calmodulin, requiring a function Asr1p Ring domain. Asr1p specifically ubiquitylates calmodulin Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information in vivo calmodulin is ubiquitylated at lysine 22 Saccharomyces cerevisiae ?
-
?
additional information purified Asr1p E3 ligase, the E1 enzyme and the E2 enzyme UbcH5a are sufficient for in vitro ubiquitylation of calmodulin, requiring a function Asr1p Ring domain Saccharomyces cerevisiae ?
-
?

Subunits

Subunits Comment Organism
More two putitive calmodulin motifs wihin Asr1p are identified that are sufficient and necessary for interaction with calmodulin Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
Asr1p
-
Saccharomyces cerevisiae
More formerly EC 6.3.2.21 Saccharomyces cerevisiae
ubiquitin E3 ligase
-
Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function involved in calcium signalling. The interaction with calmodulin occurs in vivo and depends on physiological concentrations of Ca2+ Saccharomyces cerevisiae