Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.B11 extracted from

  • Laub, M.; Jennissen, H.P.
    Synthesis and decay of calmodulin-ubiquitin conjugates in cell-free extracts of various rabbit tissues (1997), Biochim. Biophys. Acta, 1357, 173-191.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
n ATP + calmodulin + n ubiquitin Oryctolagus cuniculus the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold ?
-
?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain high activity Oryctolagus cuniculus
-
erythrocyte high activity Oryctolagus cuniculus
-
red muscle skeletal Oryctolagus cuniculus
-
reticulocyte high activity Oryctolagus cuniculus
-
spleen high activity Oryctolagus cuniculus
-
testis high activity Oryctolagus cuniculus
-
white muscle skeletal Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
n ATP + calmodulin + n ubiquitin the activity is regulated by the binding of the second messenger Ca2+ to the substrate calmodulin, which increases the activity ca. 10fold Oryctolagus cuniculus ?
-
?
[RING-E3-ubiquitin-carrier protein]-S-ubiquitinyl-L-cysteine + [calmodulin]-L-lysine
-
Oryctolagus cuniculus [RING-E3-ubiquitin-carrier protein]-L-cysteine + [calmodulin]-N6-ubiquitinyl-L-lysine
-
?

Subunits

Subunits Comment Organism
More two components of the ligase can be identified: uCaM Syn-F1 and uCaM Syn-F2, the first of which binds to ubiquitin and the second which binds to calmodulin Oryctolagus cuniculus