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Literature summary for 2.3.2.5 extracted from

  • Hartlage-Ruebsamen, M.; Morawski, M.; Waniek, A.; Jaeger, C.; Zeitschel, U.; Koch, B.; Cynis, H.; Schilling, S.; Schliebs, R.; Demuth, H.U.; Rossner, S.
    Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Abeta deposits in hippocampus via distinct cellular mechanisms (2011), Acta Neuropathol., 121, 705-719.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme is a pharmacological target for Alzheimer’s disease therapy Mus musculus
medicine the enzyme is a pharmacological target for Alzheimer’s disease therapy Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Mus musculus
-
hippocampus
-
Homo sapiens
-
neuron
-
Mus musculus
-
neuron
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Gln-2-naphthylamide
-
Mus musculus 5-oxoprolyl-2-naphthylamide + NH3
-
?
L-Gln-2-naphthylamide
-
Homo sapiens 5-oxoprolyl-2-naphthylamide + NH3
-
?

Synonyms

Synonyms Comment Organism
glutaminyl cyclase
-
Mus musculus
glutaminyl cyclase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function glutaminyl cyclase contributes to the formation of focal and diffuse diglutamate-Abeta peptide deposits in hippocampus Mus musculus
physiological function glutaminyl cyclase contributes to the formation of focal and diffuse diglutamate-Abeta peptide deposits in hippocampus Homo sapiens