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Literature summary for 2.3.2.5 extracted from

  • Schilling, S.; Appl, T.; Hoffmann, T.; Cynis, H.; Schulz, K.; Jagla, W.; Friedrich, D.; Wermann, M.; Buchholz, M.; Heiser, U.; von Hoersten, S.; Demuth, H.U.
    Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ (2008), J. Neurochem., 106, 1225-1236.
    View publication on PubMed
Search for more literature for 2.3.2.5

Cloned(Commentary)

Cloned (Comment) Organism
-
 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
benzimidazole
-
 Rattus norvegicus
benzylimidazole
-
 Rattus norvegicus
H-Gln-7-amido-4-methylcoumarin substrate inhibition Rattus norvegicus
H-Gln-beta-naphthylamide substrate inhibition Rattus norvegicus
imidazole
-
 Rattus norvegicus
N-methylimidazole
-
 Rattus norvegicus
PBD150
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain cortex high expression of QC in neurons of several cell layers of the cortex and hippocampus Rattus norvegicus
-
hippocampus high expression of QC in neurons of several cell layers of the cortex and hippocampus Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid beta(3-40)
-
 Rattus norvegicus pyroglutamyl-amyloid beta(3-40) + NH3
-
 ?
Gln-Gln
-
 Rattus norvegicus 5-oxoprolyl-Gln + NH3
-
 ?
Gln-Gly
-
 Rattus norvegicus 5-oxoprolyl-Gly + NH3
-
 ?
H-Gln-7-amido-4-methylcoumarin
-
 Rattus norvegicus 5-oxoprolyl-7-amido-4-methylcoumarin + NH3
-
 ?
H-Gln-beta-naphthylamide
-
 Rattus norvegicus 5-oxoprolyl-beta-naphthylamide + NH3
-
 ?
H-Gln-Glu-OH
-
 Rattus norvegicus 5-oxoprolyl-Glu-OH + NH3
-
 ?
H-Gln-Gly-Pro-OH
-
 Rattus norvegicus 5-oxoprolyl-Gly-Pro-OH + NH3
-
 ?
H-Gln-Phe-Arg-His-NH2
-
 Rattus norvegicus 5-oxoprolyl-Phe-Arg-His-NH2 + NH3
-
 ?

Synonyms

Synonyms Comment Organism
glutaminyl cyclase
-
 Rattus norvegicus
QC
-
 Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0001
-
 PBD150 pH 8.0, 30°C Rattus norvegicus
0.0035
-
 benzylimidazole pH 8.0, 30°C Rattus norvegicus
0.013
-
 N-methylimidazole pH 8.0, 30°C Rattus norvegicus
0.116
-
 imidazole pH 8.0, 30°C Rattus norvegicus
0.13
-
 benzimidazole pH 8.0, 30°C Rattus norvegicus
1.3
-
 H-Gln-beta-naphthylamide pH 8.0, 30°C Rattus norvegicus
4.5
-
 H-Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Rattus norvegicus