Literature summary for 2.3.2.26 extracted from

Lin, Q.; Dai, Q.; Meng, H.; Sun, A.; Wei, J.; Peng, K.; Childress, C.; Chen, M.; Shao, G.; Yang, W.
The HECT E3 ubiquitin ligase NEDD4interacts with and ubiquitylates SQSTM1 for inclusion body autophagy (2017), J. Cell Sci., 130, 3839-3850 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P46934	isoform NEDD4	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[HECT-E3-ubiquitin-carrier protein NEDD4]-S-ubiquitin-L-cysteine + [SQSTM1]-L-lysine	SQSTM1 i.e. an autophagic cargo receptor involved in selective autophagy	Homo sapiens	[HECT-E3-ubiquitin-carrier protein NEDD4]-L-cysteine + [SQSTM1]-N6-ubiquinyl-L-lysine	-	?

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Release 2023.1 (January 2023)