Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | A2A5Z6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelium | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [my-opioid receptor MOR1]-L-lysine | - |
Mus musculus | [E2 ubiquitin-conjugating enzyme]-L-cysteine + [my-opioid receptor MOR1]-N6-ubiquitinyl-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Smurf2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | Smurf2 mediates [D-Ala2,NMePhe4,Gly5-ol]-enkephalin (DAMGO, an agonist of MOR1)-induced MOR1 ubiquitination and degradation. DAMGO decreases MOR1 levels in the ubiquitin-proteasome system. MOR1 is modified by a Lys48-linked polyubiquitin chain. Overexpression of Smurf2 induces MOR1 ubiquitination and accelerates DAMGO-induced MOR1 degradation, whereas downregulation of Smurf2 attenuates MOR1 degradation. DAMGO increases lung epithelial cell migration and proliferation, and the effect is attenuated by overexpressing Smurf2 | Mus musculus |