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Literature summary for 2.3.2.26 extracted from

  • An, C.I.; Ganio, E.; Hagiwara, N.
    Trip12, a HECT domain E3 ubiquitin ligase, targets Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells (2013), Skeletal Muscle, 3, 11.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
x * 200000, SDS-PAGE Mus musculus
200000
-
x * 200000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine Mus musculus
-
[HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine
-
?
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine Homo sapiens
-
[HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14669
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
C2C12 cell
-
Mus musculus
-
liver
-
Mus musculus
-
lung
-
Mus musculus
-
myoblast
-
Mus musculus
-
skeletal muscle
-
Mus musculus
-
skeletal muscle
-
Homo sapiens
-
testis
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine
-
Mus musculus [HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine
-
?
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine
-
Homo sapiens [HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine
-
?

Subunits

Subunits Comment Organism
? x * 200000, SDS-PAGE Mus musculus
? x * 200000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
HECT domain E3 ubiquitin ligase
-
Mus musculus
HECT domain E3 ubiquitin ligase
-
Homo sapiens
TRIP12
-
Mus musculus
TRIP12
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown in C2C12 myotubes results in a concurrent increase in Sox6 protein levels and a decrease of Myh7 transcription Mus musculus
physiological function the enzyme targets transcription factor Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells Mus musculus
physiological function the enzyme targets transcription factor Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells Homo sapiens