Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
200000 | - |
x * 200000, SDS-PAGE | Mus musculus |
200000 | - |
x * 200000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine | Mus musculus | - |
[HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine | - |
? | |
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine | Homo sapiens | - |
[HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q14669 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
C2C12 cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
myoblast | - |
Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
skeletal muscle | - |
Homo sapiens | - |
testis | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine | - |
Mus musculus | [HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine | - |
? | |
S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine + [Sox6 protein]-L-lysine | - |
Homo sapiens | [HECT-type E3 ubiquitin transferase]-L-cysteine + N6-ubiquitinyl-[Sox6 protein]-L-lysine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 200000, SDS-PAGE | Mus musculus |
? | x * 200000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
HECT domain E3 ubiquitin ligase | - |
Mus musculus |
HECT domain E3 ubiquitin ligase | - |
Homo sapiens |
TRIP12 | - |
Mus musculus |
TRIP12 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown in C2C12 myotubes results in a concurrent increase in Sox6 protein levels and a decrease of Myh7 transcription | Mus musculus |
physiological function | the enzyme targets transcription factor Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells | Mus musculus |
physiological function | the enzyme targets transcription factor Sox6 for proteasomal degradation and affects fiber type-specific gene expression in muscle cells | Homo sapiens |