Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.26 extracted from

  • Otaki, Y.; Takahashi, H.; Watanabe, T.; Funayama, A.; Netsu, S.; Honda, Y.; Narumi, T.; Kadowaki, S.; Hasegawa, H.; Honda, S.; Arimoto, T.; Shishido, T.; Miyamoto, T.; Kamata, H.; Nakajima, O.; Kubota, I.
    HECT-type ubiquitin E3 ligase ITCH interacts with thioredoxin-interacting protein and ameliorates reactive oxygen species-induced cardiotoxicity (2016), J. Am. Heart Assoc., 5, e002485.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.26

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
113000
-
 x * 113000, SDS-PAGE Mus musculus
113000
-
 x * 113000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-
cardiomyocyte
-
 Rattus norvegicus
-

Subunits

Subunits Comment Organism
? x * 113000, SDS-PAGE Mus musculus
? x * 113000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
HECT-type E3 ligase
-
 Mus musculus
HECT-type E3 ligase
-
 Rattus norvegicus
HECT-type ubiquitin E3 ligase
-
 Mus musculus
HECT-type ubiquitin E3 ligase
-
 Rattus norvegicus
Itch
-
 Mus musculus
Itch
-
 Rattus norvegicus

Expression

Organism Comment Expression
Mus musculus enzyme expression is increased 3 h after Dox stimulation (0.0005 mM) up
Rattus norvegicus enzyme expression is increased 3 h after Dox stimulation (0.0005 mM) up

General Information

General Information Comment Organism
malfunction enzyme knockdown inhibits thioredoxin-interacting protein degradation and results in a subsequent increase in cardiomyocyte apoptosis Mus musculus
malfunction enzyme knockdown inhibits thioredoxin-interacting protein degradation and results in a subsequent increase in cardiomyocyte apoptosis Rattus norvegicus
physiological function the enzyme targets thioredoxin-interacting protein for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin system. The enzyme protects cardiac remodeling, cardiac function, and survival rate in myocardial infarction Mus musculus
physiological function the enzyme targets thioredoxin-interacting protein for ubiquitin-proteasome degradation in cardiomyocytes and ameliorates reactive oxygen species-induced cardiotoxicity through the thioredoxin system. The enzyme protects cardiac remodeling, cardiac function, and survival rate in myocardial infarction Rattus norvegicus