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Literature summary for 2.3.2.26 extracted from

  • Rodriguez, M.S.; Gwizdek, C.; Haguenauer-Tsapis, R.; Dargemont, C.
    The HECT ubiquitin ligase Rsp5p is required for proper nuclear export of mRNA in Saccharomyces cerevisiae (2003), Traffic, 4, 566-575.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Synonyms

Synonyms Comment Organism
RSP5
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Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function deletion of isoform Rsp5 or mutation of its ligase activity, blocks the nuclear export of mRNAs. Affected messenger RNAs include both total poly(A)+ mRNA and heat-shock mRNAs. Mutation of Rsp5 does not affect nuclear protein import or export. Deletion of RSP5 blocks mRNA export, even under conditions where its essential role in unsaturated fatty acids biosynthesis is bypassed. The ligase activity is required for proper mRNA export Saccharomyces cerevisiae