Literature summary for 2.3.2.26 extracted from

Angers, A.; Ramjaun, A.R.; McPherson, P.S.
The HECT domain ligase Itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system (2004), J. Biol. Chem., 279, 11471-11479.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	isoform Itch co-localizes with markers of the endosomal system in a C2 domain-dependent manner and upon EGF stimulation, substrate endophilin A1 translocates to an EGF-positive endosomal compartment where it colocalizes with itch	Homo sapiens	5768	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96J02	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[UbcH7]-L-cysteine + [endophilin A]-L-lysine	-	Homo sapiens	[UbcH7]-L-cysteine + N6-ubiquitinyl-[endophilin A]-L-lysine	isoform Itch ubiquitinates SH3 domain-containing protein endophilin A1 and the SH3/proline-rich domain interaction facilitates this activity. EGF treatment of cells stimulates endophilin A1 ubiquitination	?

Synonyms

Synonyms	Comment	Organism
AIP4	-	Homo sapiens
Itch	-	Homo sapiens

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Release 2023.1 (January 2023)