Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HCE7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [ING2]-L-lysine | ING2 i.e. candidate tumor suppressor Inhibitor of Growth 2 | Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[ING2]-L-lysine | isoform Smurf1 interacts with and targets ING2 for poly-ubiquitination and proteasomal degradation. The ING2 binding domain in Smurf1 was mapped to the catalytic HECT domain. The C-terminal PHD domain of ING2 is required for Smurf1-mediated degradation | ? |
Synonyms | Comment | Organism |
---|---|---|
Smurf1 | - |
Homo sapiens |