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Literature summary for 2.3.2.26 extracted from

  • Wang, R.; Kaul, Z.; Ambardekar, C.; Yamamoto, T.G.; Kavdia, K.; Kodali, K.; High, A.A.; Kitagawa, R.
    HECT-E3 ligase ETC-1 regulates securin and cyclin B1 cytoplasmic abundance to promote timely anaphase during meiosis in C. elegans (2013), Development, 140, 2149-2159.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[Ubc-18]-L-cysteine + [IFY-1]-L-lysine IFY-1 i.e. anaphase inhibitor securin Caenorhabditis elegans [Ubc-18]-L-cysteine + N6-ubiquitinyl-[IFY-1]-L-lysine
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Synonyms

Synonyms Comment Organism
ETC-1
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Caenorhabditis elegans
Ube3C
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Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function HECT-E3 ligase ETC-1 is a regulator of the cytoplasmic anaphase inhibitor securin IFY-1 level. RNAi-mediated depletion of ETC-1 stabilizes IFY-1 and cyclin B1 in post-meiosis I embryos. ETC-1 knockdown in a reduced anaphase promoting complex/cyclosome function background causes an embryonic lethal phenotype. In vitro, ETC-1 ubiquitylates IFY-1 and CYB-1 in the presence of the E2 enzyme UBC-18, which functions in pharyngeal development. UBC-18 plays a distinct role together with ETC-1 in regulating the cytoplasmic level of IFY-1 during meiosis Caenorhabditis elegans