Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-ubiquitinyl-[Ubc-18]-L-cysteine + [IFY-1]-L-lysine | IFY-1 i.e. anaphase inhibitor securin | Caenorhabditis elegans | [Ubc-18]-L-cysteine + N6-ubiquitinyl-[IFY-1]-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ETC-1 | - |
Caenorhabditis elegans |
Ube3C | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | HECT-E3 ligase ETC-1 is a regulator of the cytoplasmic anaphase inhibitor securin IFY-1 level. RNAi-mediated depletion of ETC-1 stabilizes IFY-1 and cyclin B1 in post-meiosis I embryos. ETC-1 knockdown in a reduced anaphase promoting complex/cyclosome function background causes an embryonic lethal phenotype. In vitro, ETC-1 ubiquitylates IFY-1 and CYB-1 in the presence of the E2 enzyme UBC-18, which functions in pharyngeal development. UBC-18 plays a distinct role together with ETC-1 in regulating the cytoplasmic level of IFY-1 during meiosis | Caenorhabditis elegans |