Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.26 extracted from

  • Zanier, K.; Charbonnier, S.; Baltzinger, M.; Nomine, Y.; Altschuh, D.; Trave, G.
    Kinetic analysis of the interactions of human papillomavirus E6 oncoproteins with the ubiquitin ligase E6AP using surface plasmon resonance (2005), J. Mol. Biol., 349, 401-412.
    View publication on PubMed
Search for more literature for 2.3.2.26

Application

Application Comment Organism
medicine high-risk human papilloma virus E6 oncoproteins interact with the ubiquitin ligase E6AP and target several cellular proteins, including p53 and proteins of the MAGI family, towards ubiquitin-mediated degradation. E6 oncoproteins from major high-risk risk human papilloma virus types 16, 18, 33 and 58 bind to a 15-mer peptide containing the LxxphiLsh motif of E6AP, where L indicates conserved leucine residues, phi is a hydrophobic residue, h is an amino acid residue with a side-chain capable of accepting hydrogen bonds, s represents a small amino acid residue and xx is a dipeptide where one of the residues is Asp, Asn, Glu or Gln. The equilibrium dissociation constants are in the low micromolar range. Low-risk risk human papilloma virus 11 E6 does not interact with E6AP. The two zinc-binding domains of E6 are required for E6AP recognition Homo sapiens

Protein Variants

Protein Variants Comment Organism
E411Q slight decrease of affinity to human papilloma virus E6 oncogens Homo sapiens
E411Q/E415Q about 6fold decrease of affinity to human papilloma virus E6 oncogens Homo sapiens
E415Q slight decrease of affinity to human papilloma virus E6 oncogens Homo sapiens
E415R slight decrease of affinity to human papilloma virus E6 oncogens Homo sapiens
L409V about 30fold decrease of affinity to human papilloma virus E6 oncogens characterised by very fast dissociation rates Homo sapiens
L412V moderate decrease of affinity to human papilloma virus E6 oncogens Homo sapiens
L413S about 40fold decrease of affinity to human papilloma virus E6 oncogens characterised by very fast dissociation rates Homo sapiens
L413V moderate decrease of affinity to human papilloma virus E6 oncogens Homo sapiens
Q410E no decrease of affinity to human papilloma virus E6 oncogens Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q05086 isoform E6AP
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information high-risk human papilloma virus E6 oncoproteins interact with the ubiquitin ligase E6AP and target several cellular proteins, including p53 and proteins of the MAGI family, towards ubiquitin-mediated degradation. E6 oncoproteins from major high-risk human papilloma virus types 16, 18, 33 and 58 bind to a 15-mer peptide containing the LxxphiLsh motif of E6AP, where L indicates conserved leucine residues, phi is a hydrophobic residue, h is an amino acid residue with a side-chain capable of accepting hydrogen bonds, s represents a small amino acid residue and xx is a dipeptide where one of the residues is Asp, Asn, Glu or Gln. The equilibrium dissociation constants are in the low micromolar range. Low-risk human papilloma virus 11 E6 does not interact with E6AP. The two zinc-binding domains of E6 are required for E6AP recognition Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
E6AP
-
 Homo sapiens