Literature summary for 2.3.2.26 extracted from

Hu, G.; Wang, X.; Saunders, D.; Henderson, M.; Russell, A.; Herring, B.; Zhou, J.
Modulation of myocardin function by the ubiquitin E3 ligase UBR5 (2011), J. Biol. Chem., 286, 11800-11809.

Search for more literature for 2.3.2.26

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	enzyme UBR5 localizes in the nuclei of smooth muscle cells and forms a complex with myocardin in vivo and in vitro	Mus musculus	5634	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q80TP3	isoform UBR5	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
smooth muscle	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
UBR5	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	ubiquitin ligase UBR5 specifically enhances trans-activation of smooth muscle-specific promoters by the myocardin family of proteins. UBR5 significantly augments the ability of myocardin to induce expression of endogenous smooth muscle cell marker genes independent on its E3 ligase function. Depletion of endogenous UBR5 by small interfering RNA in fibroblast cells attenuates myocardin-induced smooth muscle-specific gene expression, and UBR5 knockdown in smooth muscle cells results in down-regulation of smooth muscle-specific genes. UBR5 can attenuate myocardin protein degradation resulting in increased myocardin protein expression without affecting myocardin mRNA expression. The effects of UBR5 on myocardin requires only the HECT and UBR1 domains of UBR5	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)