Literature summary for 2.3.2.26 extracted from

Chen, A.; Gao, B.; Zhang, J.; McEwen, T.; Ye, S.Q.; Zhang, D.; Fang, D.
The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination (2009), Mol. Cell. Biol., 29, 5348-5356.

Search for more literature for 2.3.2.26

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00308	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[AIP2-ubiquitin-conjugating enzyme E2]-S-ubiquitin-L-cysteine + [EGR2]-L-lysine	EGR2, a zinc finger transcription factor that has been found to regulate Fas ligand expression during activation-induced T-cell death	Homo sapiens	[AIP2-ubiquitin-conjugating enzyme E2]-L-cysteine + [EGR2]-N6-ubiquitinyl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
AIP2	-	Homo sapiens
WWP2	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	E3 ligase AIP2 positively regulates T-cell activation. Ectopic expression of AIP2 in mouse primary T cells enhances their proliferation and interleukin-2 production by suppressing the apoptosis of T cells. AIP2 interacts with and promotes ubiquitin-mediated degradation of EGR2, a zinc finger transcription factor that has been found to regulate Fas ligand expression during activation-induced T-cell death. Suppression of AIP2 expression by small RNA interference upregulates EGR2, inhibits EGR2 ubiquitination and Fas ligand expression, and enhances the apoptosis of T cells	Homo sapiens

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Release 2023.1 (January 2023)