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Literature summary for 2.3.2.26 extracted from

  • Xia, Z.; Webster, A.; Du, F.; Piatkov, K.; Ghislain, M.; Varshavsky, A.
    Substrate-binding sites of UBR1, the ubiquitin ligase of the N-end rule pathway (2008), J. Biol. Chem., 283, 24011-24028.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P19812
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Saccharomyces cerevisiae ATCC 204508 P19812
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the type-1/2 substrate-binding sites of isoform UBR1, are located in the first 700 residues of the 1950-residue enzyme. Type-1 site is specific for basic N-terminal residues Arg, Lys, and His. The type-2 site is specific for bulky hydrophobic N-terminal residues Trp, Phe, Tyr, Leu, and Ile. Isoform UBR1 binds, with a Kd of about 1microM to either type-1 or type-2 N-terminal residues of reporter peptides but does not bind to a stabilizing N-terminal residue such as Gly Saccharomyces cerevisiae ?
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additional information UBR1 and CUP9, a transcriptional repressor of peptide import, interact nonspecifically and specific binding which involves, in particular, the binding by cognate dipeptides to theUBR1 type-1/2 substrate-binding sites, can be restored either by a chaperone such as EF1A or through macromolecular crowding Saccharomyces cerevisiae ?
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?
additional information the type-1/2 substrate-binding sites of isoform UBR1, are located in the first 700 residues of the 1950-residue enzyme. Type-1 site is specific for basic N-terminal residues Arg, Lys, and His. The type-2 site is specific for bulky hydrophobic N-terminal residues Trp, Phe, Tyr, Leu, and Ile. Isoform UBR1 binds, with a Kd of about 1microM to either type-1 or type-2 N-terminal residues of reporter peptides but does not bind to a stabilizing N-terminal residue such as Gly Saccharomyces cerevisiae ATCC 204508 ?
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?
additional information UBR1 and CUP9, a transcriptional repressor of peptide import, interact nonspecifically and specific binding which involves, in particular, the binding by cognate dipeptides to theUBR1 type-1/2 substrate-binding sites, can be restored either by a chaperone such as EF1A or through macromolecular crowding Saccharomyces cerevisiae ATCC 204508 ?
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?

Synonyms

Synonyms Comment Organism
UBR1
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Saccharomyces cerevisiae