Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00762 | - |
- |
Homo sapiens | P60604 | - |
- |
Homo sapiens | P61086 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | E3-independent ubiquitination by Ube2K produces unanchored but also Ube2K-linked polyubiquitins through thioester and isopeptide bonds. E3-independent assembly of polyubiquitins on the catalytic cysteine of Ube2K strongly supports the possibility of en bloc transfer for polyubiquitination. Different lengths of polyubiquitins are linked to different E2s through thioester bond. In vitro E3-independent ubiquitination by Ube2K simultaneously produces unanchored, isopeptde-linked, and thioester-linked polyubiquitin chains | Homo sapiens | ? | - |
? | |
additional information | isoform UbcH10 does not preassemble polyubiquitin chains on its acitve site cysteine | Homo sapiens | ? | - |
? | |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + S-(ubiquitin)n-Ube2g2-L-cysteine | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + S-(ubiquitin)(n+1)-Ube2g2-L-cysteine | short chains of polyubiquitins can be linked bonds to E2 enzyme Ube2g2 | ? | |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + S-(ubiquitin)n-Ube2K-L-cysteine | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + S-(ubiquitin)(n+1)-Ube2K-L-cysteine | longer chains of polyubiquitins can be linked bonds to E2 enzyme Ube2K. Ubiquitin chains are assembled on the active site cysteine of Ube2K through thioester bond | ? | |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + UbcH10-L-cysteine | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-UbcH10-L-cysteine | - |
? | |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + Ube2g2-L-cysteine | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-Ube2g2-L-cysteine | - |
? | |
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + Ube2K-L-cysteine | - |
Homo sapiens | [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-Ube2K-L-cysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UbcH10 | - |
Homo sapiens |
UBE2C | - |
Homo sapiens |
UBE2G2 | - |
Homo sapiens |
UBE2K | - |
Homo sapiens |