Literature summary for 2.3.2.23 extracted from

Aichem, A.; Catone, N.; Groettrup, M.
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1 (2014), FEBS J., 281, 1848-1859.

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Protein Variants

Protein Variants	Comment	Organism
K323R	mutation in site of auto-FAT10ylation. Mutation does not abolish auto-FAT10ylation of USE1, but every other lysine can instead be modified with FAT10	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9H832	-	-

Synonyms

Synonyms	Comment	Organism
UBA6-specific E2 enzyme 1	-	Homo sapiens
ubiquitin-conjugating enzyme E2 Z	-	Homo sapiens
USE1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	USE1 modifies itself with HLA-F adjacent transcript 10, i.e. FAT10, in cis, mainly at Lys323. Mutation of Lys323 to an arginine does not abolish auto-FAT10ylation of USE1, but every other lysine can instead be modified with FAT10. FAT10ylation of USE1 accelerates its proteasomal degradation. The USE1FAT10 conjugate continues to be an active E2 enzyme	Homo sapiens

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Release 2023.1 (January 2023)