Literature summary for 2.3.2.21 extracted from

Vetting, M.W.; Hegde, S.S.; Blanchard, J.S.
The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase (2010), Nat. Chem. Biol., 6, 797-799.

Search for more literature for 2.3.2.21

Crystallization (Commentary)

Crystallization (Comment)	Organism
to 2.0 A resolution. Gene product Rv2275 is structurally related to the class Ic aminoacyl-tRNA-synthetase family of enzymes. Reaction proceeds via a covalent intermediate in which L-tyrosine is transferred from Tyr-tRNATyr to an active site serine, S88, by transesterification and with residue E233 serving as a critical base catalyzing dipeptide bond formation	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WPF9	putative	-
Mycobacterium tuberculosis H37Rv	P9WPF9	putative	-

Reaction

Reaction	Comment	Organism	Reaction ID
2 L-tyrosyl-tRNATyr = 2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)	reaction proceeds via a covalent intermediate in which L-tyrosine is transferred from Tyr-tRNATyr to an active site serine, S88, by transesterification and with residue E233 serving as a critical base catalyzing dipeptide bond formation	Mycobacterium tuberculosis	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 L-tyrosyl-tRNATyr	-	Mycobacterium tuberculosis	2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)	-	?
2 L-tyrosyl-tRNATyr	-	Mycobacterium tuberculosis H37Rv	2 tRNATyr + cyclo(L-tyrosyl-L-tyrosyl)	-	?

Synonyms

Synonyms	Comment	Organism
cyclodityrosine synthetase	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)