Literature summary for 2.3.2.2 extracted from

Wainford, R.D.; Weaver, R.J.; Stewart, K.N.; Brown, P.; Hawksworth, G.M.
Cisplatin nephrotoxicity is mediated by gamma glutamyltranspeptidase, not via a C-S lyase governed biotransformation pathway (2008), Toxicology, 249, 184-193.

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Application

Application	Comment	Organism
pharmacology	cisplatin administration significantly elevates blood urea nitrogen and serum creatinine in male rats day 5 post-treatment. Inhibition of gamma glutamyltranspeptidase prevents cisplatin nephrotoxicity, but not cellular toxicity in rat proximal tubular cultures	Rattus norvegicus
pharmacology	cisplatin administration significantly elevates blood urea nitrogen and serum creatinine in mice day 4 post-treatment. Inhibition of gamma glutamyltranspeptidase prevents cisplatin nephrotoxicity	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Rattus norvegicus	-	-	-

General Information

General Information	Comment	Organism
physiological function	gamma glutamyltranspeptidase is a key enzyme involved in mediating cisplatin nephrotoxicity, which potentially acts to cleave cisplatin-GSH conjugates to a toxic metabolite	Mus musculus
physiological function	gamma glutamyltranspeptidase is a key enzyme involved in mediating cisplatin nephrotoxicity, which potentially acts to cleave cisplatin-GSH conjugates to a toxic metabolite	Rattus norvegicus

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Release 2023.1 (January 2023)