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Literature summary for 2.3.2.2 extracted from
- The human gamma-glutamyltransferase gene family (2008), Hum. Genet., 123, 321-332.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | assays for gamma-glutamyl transferase (GGT1) activity in blood are widely used in a clinical setting to measure tissue damage | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| vacuole | GGT1 is an extracellular enzyme that is anchored to the plasma membrane of cells | Homo sapiens | 5773 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | GGT1 hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. It has a critical function in the metabolism of glutathione and in the conversion of the leukotriene LTC4 to LTD4 | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P19440 | precursor | - |
| Homo sapiens | P36269 | precursor | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| bladder | - |
Homo sapiens | - |
| blood | - |
Homo sapiens | - |
| lymph | - |
Homo sapiens | - |
| mammary gland | - |
Homo sapiens | - |
| additional information | activity of GGT1 is increased in liver disease, oxidative stress and metabolic syndrome | Homo sapiens | - |
| prostate | - |
Homo sapiens | - |
| spleen | - |
Homo sapiens | - |
| thymus | - |
Homo sapiens | - |
| vascular tissue | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | GGT1 hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors. It has a critical function in the metabolism of glutathione and in the conversion of the leukotriene LTC4 to LTD4 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GGT1 | - |
Homo sapiens |
| GGT5 | - |
Homo sapiens |
| GGTLA1 | formerly | Homo sapiens |
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Release 2023.1 (January 2023)
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