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Literature summary for 2.3.2.2 extracted from

  • Keren, R.; Stark, A.A.
    gamma-Glutamyl transpeptidase-dependent mutagenicity and cytotoxicity of gamma-glutamyl derivatives: a model for biochemical targeting of chemotherapeutic agents (1998), Environ. Mol. Mutagen., 32, 377-386.
    View publication on PubMed

Application

Application Comment Organism
medicine bioconversion of cytotoxic and mutagenic agents to inactive 5-L-glutamyl-derivatives Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
4-nitroaniline cytotoxic, weakly mutagenic Rattus norvegicus
5-glutamylphenylhydrazides no inhibition and cytotoxity Rattus norvegicus
daunomycin cytotoxic and mutagenic Rattus norvegicus
L- or D-Serine/borate competitive Rattus norvegicus
additional information
-
Rattus norvegicus
phenylhydrazides cytotoxic and mutagenic Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-D/L-glutamyl-phenylhydrazine + acceptor Rattus norvegicus
-
phenylhydrazine + 5-L-glutamyl-acceptor product is cytotoxic ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid kinetic study Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+ concurrent reaction: hydrolase reaction with H2O as acceptor Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
ir
(5-L-glutamyl)-peptide + acceptor + H+ acceptor specificity, overview Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
ir
(5-L-glutamyl)-peptide + acceptor + H+ donor specificity, overview Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
ir
5-D/L-glutamyl-phenylhydrazine + acceptor
-
Rattus norvegicus phenylhydrazine + 5-L-glutamyl-acceptor product is cytotoxic ir
5-L-glutamyl-4-nitroanilide + glycylglycine
-
Rattus norvegicus 4-nitroaniline + 5-L-glutamylglycylglycine 4-nitroaniline is cytotoxic ?
glutathione + daunomycin detoxification of daunomycin by transpeptidation Rattus norvegicus L-cysteinylglycine + 5-L-glutamyl-daunomycin
-
ir

Synonyms

Synonyms Comment Organism
GGT
-
Rattus norvegicus