Application | Comment | Organism |
---|---|---|
medicine | bioconversion of cytotoxic and mutagenic agents to inactive 5-L-glutamyl-derivatives | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-nitroaniline | cytotoxic, weakly mutagenic | Rattus norvegicus | |
5-glutamylphenylhydrazides | no inhibition and cytotoxity | Rattus norvegicus | |
daunomycin | cytotoxic and mutagenic | Rattus norvegicus | |
L- or D-Serine/borate | competitive | Rattus norvegicus | |
additional information | - |
Rattus norvegicus | |
phenylhydrazides | cytotoxic and mutagenic | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-D/L-glutamyl-phenylhydrazine + acceptor | Rattus norvegicus | - |
phenylhydrazine + 5-L-glutamyl-acceptor | product is cytotoxic | ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid | kinetic study | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5-L-glutamyl)-peptide + acceptor + H+ | concurrent reaction: hydrolase reaction with H2O as acceptor | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
ir | |
(5-L-glutamyl)-peptide + acceptor + H+ | acceptor specificity, overview | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
ir | |
(5-L-glutamyl)-peptide + acceptor + H+ | donor specificity, overview | Rattus norvegicus | peptide + 5-L-glutamyl amino acid | - |
ir | |
5-D/L-glutamyl-phenylhydrazine + acceptor | - |
Rattus norvegicus | phenylhydrazine + 5-L-glutamyl-acceptor | product is cytotoxic | ir | |
5-L-glutamyl-4-nitroanilide + glycylglycine | - |
Rattus norvegicus | 4-nitroaniline + 5-L-glutamylglycylglycine | 4-nitroaniline is cytotoxic | ? | |
glutathione + daunomycin | detoxification of daunomycin by transpeptidation | Rattus norvegicus | L-cysteinylglycine + 5-L-glutamyl-daunomycin | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
GGT | - |
Rattus norvegicus |