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Literature summary for 2.3.2.2 extracted from

  • Bernström, K.; Orning, L.; Hammarström, S.
    gamma-Glutamyl transpeptidase, a leukotriene metabolizing enzyme (1982), Methods Enzymol., 86, 38-45.
    View publication on PubMed
Search for more literature for 2.3.2.2

Activating Compound

Activating Compound Comment Organism Structure
Free bile acids activation Rattus norvegicus
Free bile acids activation Sus scrofa
Maleate
-
 Rattus norvegicus
Maleate
-
 Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
L- or D-Serine/borate
-
 Rattus norvegicus
L- or D-Serine/borate transition-state inhibitor Sus scrofa
L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazolacetic acid i.e. acivicin; strong, irreversible, reacts with glutamyl binding site Sus scrofa
Phenobarbital
-
 Rattus norvegicus
Phenobarbital
-
 Sus scrofa
Thiobarbituric acid
-
 Rattus norvegicus
Thiobarbituric acid
-
 Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic study Rattus norvegicus
additional information
-
 additional information kinetic study Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-
membrane
-
 Sus scrofa 16020
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa
papain Rattus norvegicus
Triton X-100 Rattus norvegicus

Reaction

Reaction Comment Organism Reaction ID
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid mechanism Rattus norvegicus
a
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid mechanism Sus scrofa
a
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid kinetic study Rattus norvegicus
a
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid kinetic study Sus scrofa
a

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
kidney
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
792
-
 purified enzyme Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5-L-glutamyl)-peptide + acceptor + H+ donors: 5-ethyl-Glu and beta-benzyl-Glu, hydrolyzed by pig enzyme Sus scrofa peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donors: ophthalmic acid, poly-5-Glu-derivatives, L-5-Glu-7-amino-4-methylcoumarin Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donors: ophthalmic acid, poly-5-Glu-derivatives, L-5-Glu-7-amino-4-methylcoumarin Sus scrofa peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: leukotriene C Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: leukotriene C Sus scrofa peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ Glu-donor is GSH Sus scrofa peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: glutathione disulfide Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: glutathione disulfide Sus scrofa peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: S-acetophenoneglutathione Rattus norvegicus peptide + 5-L-glutamyl amino acid
-
 ?
(5-L-glutamyl)-peptide + acceptor + H+ donor: S-acetophenoneglutathione Sus scrofa peptide + 5-L-glutamyl amino acid
-
 ?
5-L-glutamyl-4-nitroanilide + L-cystine best acceptor Rattus norvegicus 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
5-L-glutamyl-4-nitroanilide + L-cystine best acceptor Sus scrofa 4-nitroaniline + 5-L-glutamyl-L-cystine
-
 ?
5-L-glutamyl-7-amido-4-methylcoumarin + glycylglycine
-
 Rattus norvegicus 7-amino-4-methylcoumarin + 5-L-glutamyl-glycylglycine
-
 ?
5-L-glutamyl-7-amido-4-methylcoumarin + glycylglycine
-
 Sus scrofa 7-amino-4-methylcoumarin + 5-L-glutamyl-glycylglycine
-
 ?
glutathione + acceptor best donor Rattus norvegicus cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
glutathione + acceptor best donor Sus scrofa cysteinylglycine + 5-L-glutamyl-acceptor
-
 ?
glutathione + leukotriene D
-
 Sus scrofa cysteinylglycine + leukotriene C
-
 ?
leukotriene C4 + acceptor i.e. glutathione containing derivative of arachidonic acid, acceptors are H2O, amino acids or dipeptides Rattus norvegicus leukotriene D4 + glutamyl-acceptor
-
 ?
leukotriene C4 + acceptor i.e. glutathione containing derivative of arachidonic acid, acceptors are H2O, amino acids or dipeptides Sus scrofa leukotriene D4 + glutamyl-acceptor
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus
37
-
 assay at Sus scrofa